Monoclonal Antibodies

Bajoria S, Antunez LR, Kumru OS, Klempner M, Wang Y, Cavacini LA, Joshi SB, Volkin DB. “Formulation studies to develop low-cost, orally-delivered secretory IgA monoclonal antibodies for passive immunization against enterotoxigenic escherichia coli" J Pharm Sci 112(7):1832-1844 (2023)

Hu Y, Kumru OS, Xiong J, Antunez LR, Hickey J, Wang Y, Cavacini L, Klempner M, Joshi SB, Volkin DB. “Preformulation characterization and stability assessments of secretory IgA monoclonal antibodies as potential candidates for passive immunization by oral administration” J. Pharm Sci. 109(1):407-421 (2020)

Whitaker N, Pace S, Merritt K, Tadros M, Khossravi M, Deshmukh S, Cheng Y, Joshi SB, Volkin DB, Dhar P “Developability assessments of monoclonal antibody candidates to minimize aggregation during large-scale ultrafiltration and diafiltration (UF-DF) processing” J. Pharm Sci.111(11):2998-3008 (2022)

Jiskoot W, Hawe A, Menzen T, Volkin DB, Crommelin DJA. "Ongoing challenges to develop high concentration monoclonal antibody-based formulations for subcutaneous administration: Quo Vadis?" J Pharm Sci 111(4):861-867 (2021)

Teh AY, Cavacini L, Hu Y, Kumru OS, Xiong J, Bolick DT, Joshi SB, Grünwald-Gruber C, Altmann F, Klempner M, Guerrant RL, Volkin DB, Wang Y, Ma JK “Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants” Gut Microbes 13(1):1-14 (2021)

Jester BW, Zhao H, Gewe M, Adame T, Perruzza L, Bolick DT, Agosti J, Khuong N, Kuestner R, Gamble C, Cruickshank K, Ferrara J, Lim R, Paddock T, Brady C, Ertel S, Zhang M, Pollock A, Lee J, Xiong J, Tasch M, Saveria T, Doughty D, Marshall J, Carrieri D, Goetsch L, Dang J, Sanjaya N, Fletcher D, Martinez A, Kaldis B, Sigmar K, Afreen E, Nguyen T, Randolph A, Taber A, Krzeszowski A, Robinett B, Volkin DB, Grassi F, Guerrant R, Takeuchi R, Finrow B, Behnke C, Roberts J. “Development of spirulina for the manufacture and oral delivery of protein therapeutics” Nat. Biotechnol 40(6):956-964 (2022)

Griffin VP, Merrit K, Vaclaw C, Whitaker N, Volkin DB, Ogunyankin MO, Pace S, Dhar P,. “Evaluating the combined impact of temperature and application of interfacial dilatational stresses on surface-mediated protein particle formation in monoclonal antibody formulations” J. Pharm Sci  111(3): 680-689 (2021)

Vaclaw C, Merritt K, Griffin V, Whitaker N, Gokhale M, Volkin DB, Ogunyankin MO, Dhar P. “Comparison of protein particle formation in IgG1 mAbs formulated with PS20 Vs. PS80 when subjected to interfacial dilatational stress” J Pham Sci. 24(5):104 (2023)